About Kid's DentaBiotic™

Kid’s DentaBiotic™ is a complete new approach to managing oral health and hygiene. The unique Kid’s DentaBiotic™ formulation provides natural protection for teeth & gums with probiotic.

Kid’s DentaBiotic™ is a probiotic dietary food supplement offered as a lozenge/chewable tablet with flavor of red berry and cherry.

The probiotic strain; Lactobacillus salivarius Oral S1 has been carefully selected due to its excellent ability to inhibit the growth of pathogen organisms connected with dental caries and poor gum health. Kid’s DentaBiotic™ is manufactured in cGMP FDA Approved Facility.

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Dental cavities (dental caries)

Dental caries is one of the most widespread oral conditions globally with a suggested prevalence of 35 % in the general population (Marcenes 2013). Dental caries or tooth decay is the process of continuous demineralization and remineralization of the tooth surface caused by bacterial metabolism, skewing this balance towards demineralization (Strużycka 2014). This leads to the formation of cavities on the surface of the tooth.

Changes to the oral microbiota results in an overgrowth of various bacteria, which frequently include different species of Streptococcus (S.), e.g. S. mutans and S. gordonii. These types of bacteria are strongly associated with initiation of dental caries (Costalonga & Herzberg 2014).

Periodontal disease
Periodontal disease is also a common condition, proposed to be experienced by 10-15% of the global population with suggestions of prevalence between 50-85 % for specific populations (How 2016; Petersen & Ogawa 2012; Shewale 2016).

Periodontal disease is typically divided into gingivitis and periodontitis. Both conditions are defined as inflammation of tissue related to teeth, where gingivitis is confined to inflammation of the gum tissue and periodontitis is characterized by inflammation of the underlying bone tissue supporting the tooth in addition to inflammation of the gum (Silva 2015). Furthermore, gingivitis is generally recognized as a reversible stage of periodontal disease (Duran-Pinedo & Frias-Lopez 2015).

Halitosis
Halitosis is the common medical term for bad breath, which is primarily caused by sulphur-containing compounds produced by bacteria in the oral cavity (Madhushankari 2015). Although the prevalence of halitosis can vary greatly, it has been suggested that the prevalence of halitosis is 50 % in the general population. Furthermore, the bacteria involved in the development of halitosis are also typically associated with periodontal disease (Aylıkсı 2013).

Probiotics
Probiotic bacteria are defined by FAO/WHO in 2001 as:

"live microorganisms which when administered in adequate amounts confer a health benefit on the host"

For decades probiotics have been used to improve gut health by maintaining or restoring the microbiota in the intestines. However, it is still quite new to most people that we have a balanced microbiota in our mouth as well and this balance can also be maintained or restored with probiotics. It is a natural and ecologic way of maintaining good oral health.

Probiotics can work through a range of different mechanisms to apply their beneficial effects on oral health. These modes of action are thought to involve both local and systemic interactions. The general mechanisms utilized include competition with pathogens for nutrients and binding sites on surfaces in the oral cavity, as well as production of antimicrobial substances and modulation of the mucosal immune system through cytokine regulation (Rastogi 2011; Anusha 2015)

 



Probiotics for oral health care
A healthy mouth is not a mouth that lacks bacteria but a mouth with a healthy natural balance of many different bacteria – in fact, it has been estimated that the oral cavity can harbor up to 700 different bacterial species (Duran-Pinedo & Frias-Lopez 2015). Therefore, a new approach to managing oral hygiene is to maintain a natural and healthy microbiota in the oral cavity with probiotics.

Given the broad number of possible mechanisms of action that probiotics can utilize, they hold the potential to affect oral health in general. This was recently shown in a meta-analysis of 50 studies on different factors related to oral health. Consumption of probiotics was shown to reduce the numbers of bacteria associated with dental caries, as well as improving parameters linked to periodontal conditions (Gruner 2016). Furthermore, it was also highlighted in the meta-analysis that the majority of studies were performed with lactobacilli as probiotic bacteria, supporting the substantial contribution on oral health that these particular probiotic bacteria can elicit.

One species of lactobacilli that holds the potential of affecting oral health is Lactobacillus (L.) salivarius. A number of L. salivarius strains have been tested in vitro for their ability to co-aggregate with oral pathogens, modulate production of toxins from oral pathogens, inhibit growth of oral pathogens, as well as being able to produce hydrogen peroxide and other antibacterial compounds against oral pathogens and inhibiting the production of compounds inducing bad breath (halitosis) (Snel 2011; Nissen 2014; Chen 2012; Jang 2016).

Furthermore, a strain of L. salivarius has also been able to significantly reduce the number of S. mutans in a clinical study, when consumed for a period of two weeks (Nishihara 2014). These studies strongly indicate the potential of L. salivarius strains as probiotic candidates
to support oral health.

Selection of the Oral S1 strain
The L. salivarius Oral S1 strain in Kid’s DentaBiotic™ has been carefully selected and has, as the strains described above, shown an excellent capability of inhibiting the growth of different oral pathogens.

L. salivarius Oral S1 was the best strain in a growth inhibition study performed in close collaboration with one of the leading researchers within probiotics and odontology at University of Copenhagen.

12 probiotic strains were tested in vitro for the ability to inhibit growth of pathogens connected with dental caries and periodontal disease: S. mutans, S. gordonii, P. gingivalis, P. intermedia, A. actinomycetemcomitans and F. nucleatum.

The strain Oral S1 was superior as it was able to inhibit all six pathogens and even showed effect at concentrations as low as 10 Cell Forming Units (CFU) per mL (Keller 2013).



Complementary ingredients
Kid’s DentaBiotic™ contains the vegetable gelling agent locust bean gum that helps the probiotics to stay in the mouth for a prolonged time.

How to use Kid’s DentaBiotic™
Kid’s DentaBiotic™ is suitable for children from 3 years of age to use on a daily basis. Recommended dosage is one lozenge a day to help maintain healthy teeth and for supporting a healthy balance of the oral microbiota. Allow the lozenge to dissolve slowly in the mouth, preferably immediately after tooth brushing. If possible do not drink or eat for the following 30 minutes.

The lozenge can also be chewed thoroughly. The product is intended as a supplement to maintain or restore the natural microbiota in the mouth. It is not intended to replace the daily flossing and tooth brushing with fluorinated toothpaste.

Stability
Based on SciBiotics’s extensive expertise within probiotic strain selection, product formulation and manufacturing, Kid’s DentaBiotic™ has been designed to have a shelf-life of 24 months when stored at max. 25° C.

 

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REFERENCES:

Anusha RL, Umar D, Basheer B, Baroudi K, 2015. The magic of magic bugs in oral cavity: probiotics. J Adv Pharm Technol Res; 6(2): 43-47.

Aylıkcı BU, Çolak H, 2013. Halitosis: From diagnosis to management. J Nat Sc Biol Med; 4: 14-23.

Chen L.-J., Tsai H.-T., Chen W.-J., Hsieh C.-Y., Wang P.-C., Chen C.-S., Wang L, Yang C.-C., 2012. In vitro antagonistic growth effects of Lactobacillus fermentum and Lactobacillus salivarius and their fermentative broth on periodontal pathogens. Braz J Microbiol; 43(4): 1376-1384.

Costalonga M, Herzberg MC, 2014. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett; 162(2, part A): 22-38.

Duran-Pinedo AE, Frias-Lopez J, 2015. Beyond microbial community composition: functional activities of the oral microbiome in health and disease. Microbes Infect; 17(7): 505-516.

Gruner D, Paris S, Schwendicke F, 2016. Probiotics for managing caries and periodontitis: Systematic review and meta-analysis. J Dent; 48: 16-25.

How KY, Song KP, Chan KG, 2016. Porphyromonas gingivalis: An overview of periodontopathic pathogen below the gum line. Front Microbiol; 7(53): 1-14.

Jang H.-J., Kang M.-S., Yi S.-H., Hong J.-Y., Hong S.-P., 2016. Comparative study on the characteristics of Weissella cibaria CMU and probiotic strains for oral care. Molecules; 21: 1752.

Keller MK. Growth inhibition of oral pathogens by probiotic lactobacilli strains. 2013. Internal report: SciBiotics A/S and Section for Cariology & Endodontics and Paedodontics & Clinical Genetics, University of Copenhagen

Madhushankari GS, Yamunadevi A, Selvamani M, Kumar KPM, Basandi PS, 2015. Halitosis – An overview: Part-I – Classification, etiology, and pathophysiology of halitosis. J Pharm Bioallied Sci; 7(Suppl 2): S339- S343.

Marcenes W, Kassebaum NJ, Bernabé E, Flaxman A, Naghavi M, Lopez A, Murray CJL, 2013. Global burden of oral conditions in 1990-2010: A systematic analysis. J Dent Res; 92(7): 592-597.

Nishihara T, Suzuki N, Yoneda M, Hirofuji T, 2014. Effects of Lactobacillus salivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health; 14: 110.

Nissen L, Sgorbati B, Biavati B, Belibasakis GN, 2014. Lactobacillus salivarius and L. gasseri down-regulate Aggregatibacter actinomycetemcomitans exotoxins expression. Ann Microbiol; 64(2):611-617.

Petersen PE, Ogawa H, 2012. The global burden of periodontal disease: towards integration with chronic disease prevention and control. Periodontol 2000; 60(1): 15-39.

Rastogi P, Saini H, Dixit J, Singhal R, 2011. Probiotics and oral health.
Natl J Maxillofac Surg; 2(1): 6-9.

Shewale AH, Gattani DR, Bhatia N, Mahajan R, Saravanan SP, 2016. Prevalence of periodontal disease in the general population of India – A systematic review. J Clin Diagnostic Res; 10(6): ZE04-ZE09.

Silva N., Abusleme L., Bravo D., Dutzan N., Garcia-Sesnich J., Vernal R., Hernández M., Gamonal J., 2015. Host response mechanisms in periodontal diseases. J Appl Oral Sci; 23(3); pp. 329-355.

Snel J, Marco ML, Kingma F, Noordman WM, Rademaker J,
Kleerebezem M, 2011. Competitive selection of lactic acid bacteria that persist in the human oral cavity. Appl Environ Microbiol; 77(23): 8445-8450.

Strużycka I, 2014. The oral microbiome in dental caries. Polish J Microbiol; 63(2): 127-135.

World Health Organization & Food and Agriculture Organization of the United Nations, 2006. Probiotics in food: Health and nutritional properties and guidelines for evaluation. FAO Food and Nutritionpaper 85: p. 2

 

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